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雖然小的非編碼RNA測(cè)序數(shù)據(jù)的數(shù)量不斷增加，但仍然不清楚小RNA在人類基因組中的代表程度。薩爾大學(xué)的研究人員已經(jīng)分析了來(lái)自近25,000個(gè)數(shù)據(jù)集的3030億個(gè)測(cè)序讀數(shù)來(lái)回答這個(gè)問(wèn)題。

While many cells in our bodies can accumulate oncogenic mutations, the majority of these events do not lead to tumor formation as these abnormal cells are eliminated by defense mechanisms. Instead, tumors arise when a mutation happens in a p

雖然我們體內(nèi)的許多細(xì)胞可以積累致癌突變，但這些事件中的大多數(shù)不會(huì)導(dǎo)致腫瘤形成，因?yàn)檫@些異常細(xì)胞被防御機(jī)制消除。相反，當(dāng)突變發(fā)生在對(duì)其特異性敏感的特定細(xì)胞類型中時(shí)

單細(xì)胞mRNA測(cè)序(scRNA-seq)允許分析異質(zhì)細(xì)胞群，提供解決各種生物和醫(yī)學(xué)問(wèn)題的令人興奮的可能性。最近開發(fā)了一系列方法，因此有必要系統(tǒng)地比較它們的靈敏度，準(zhǔn)確度，精度和成本效

Single-cell mRNA sequencing (scRNA-seq) allows to profile heterogeneous cell populations, offering exciting possibilities to tackle a variety of biological and medical questions. A range of methods has been recently developed, making it nece

To treat and prevent pregnancy-related disorders, researchers must understand not only what can go wrong, but when. Complications, such as preeclampsia and pre-term birth, often occur in the second or third trimester, and most research to da

為了治療和預(yù)防與妊娠有關(guān)的疾病，研究人員不僅要了解可能出現(xiàn)的問(wèn)題，還要了解何時(shí)出錯(cuò)。并發(fā)癥如先兆子癇和早產(chǎn)，通常發(fā)生在妊娠中期或妊娠晚期，迄今為止的大多數(shù)研究都集

單細(xì)胞RNA-seq揭示了細(xì)胞群中固有的細(xì)胞異質(zhì)性，這在許多臨床和研究應(yīng)用中非常重要。